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Action potentials and saltatory conductionEdexcel International A Level Biology: Mind map

Resting potential
Depolarisation

Action potentials

Impulses along an axon

−70 mV+40 mVNodes
Repolarisation
One direction
Saltatory conduction

Exam questions on Action potentials and saltatory conduction

  1. A neuroscientist stimulates an axon in a laboratory and records the potential difference across its membrane. At rest the inside of the axon is at −70 mV relative to the outside. After a stimulus the potential difference rises rapidly to +40 mV and then falls back to −70 mV.
    Explain why the inside of the axon is negative relative to the outside at rest.2 marks
  2. Tetrodotoxin (TTX), a poison found in pufferfish, blocks the voltage-gated sodium ion channels in axon membranes. A different laboratory chemical blocks only the voltage-gated potassium ion channels.
    Explain why a person poisoned with TTX becomes paralysed.2 marks
  3. Two axons of the same diameter and 0.50 m long are compared. Axon A is myelinated and conducts impulses at 50 m s⁻¹. Axon B is unmyelinated and conducts impulses at 1.0 m s⁻¹.
    Explain why axon A conducts impulses faster than axon B.3 marks
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Written by the Exaim team, led by Shaun Daswani (Head of Upper Secondary, Improve ME Institute; MSc Financial Mathematics, Imperial College London; BSc, UCL) and Jason Daswani (operational lead, Improve ME Institute; LSE).