D1.3 Mutation and gene editing Quiz
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5 questions, one answer each
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1. Which mutation is most likely to make a polypeptide non-functional?
- A. A silent substitution
- B. A single-base insertion near the start of the gene
- C. A substitution in the third base of a codon
- D. Deletion of one whole codon near the end
2. HL: What does gene knockout investigate?
- A. The number of chromosomes
- B. The function of a gene
- C. The mutation rate of a species
- D. The age of a fossil
3. HL: In CRISPR–Cas9 editing, what determines where the DNA is cut?
- A. The length of Cas9
- B. The base sequence of the guide RNA
- C. The number of histones
- D. The position of the centromere
4. HL: Why is editing a human embryo more controversial than editing adult blood stem cells?
- A. Embryo edits are cheaper
- B. Embryo edits can be inherited by future generations
- C. Adult cells cannot be edited
- D. Embryo edits never work
5. HL: Which evidence best supports the functional-requirement hypothesis for a highly conserved protein?
- A. Its gene is very short
- B. Its DNA has many silent third-base differences but few amino acid changes
- C. It is found only in mammals
- D. It evolves faster than fibrinopeptides