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Atherosclerosis, blood clotting and cardiovascular diseaseEdexcel A-Level Biology A: Flashcards

What these 13 flashcards ask

  • What is the endothelium?
  • What is the first stage in the development of atherosclerosis?
  • What can damage the endothelium?
  • What happens in the inflammatory response in atherosclerosis?
  • What is a plaque (atheroma)?
  • Why does atherosclerosis raise blood pressure?
  • What is released by damaged tissue to start clotting?
  • What does thromboplastin do?
  • What does thrombin do?
  • What is the function of fibrin in a blood clot?
  • What is a myocardial infarction?
  • How can a blood clot cause a stroke?
  • What is an embolus?

Exam questions on Atherosclerosis, blood clotting and cardiovascular disease

  1. A 58-year-old man is told that he has atherosclerosis in his coronary arteries. His doctor explains that it develops slowly over many years and often begins when the lining of an artery is damaged.
    Explain how atherosclerosis can lead to raised blood pressure.2 marks
  2. A woman cuts her finger on a knife. The wound bleeds for a short time and then a clot forms and stops the bleeding within a few minutes.
    Describe the role of thrombin in the formation of a blood clot.2 marks
  3. A 62-year-old man has had high blood pressure for many years and has atherosclerosis in one of his coronary arteries. One day a plaque in this artery ruptures and a blood clot forms that blocks the artery completely. He has a myocardial infarction (heart attack).
    Explain how long-term high blood pressure can lead to the development of atherosclerosis, and how atherosclerosis can in turn raise blood pressure further.3 marks
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Written by the Exaim team, led by Shaun Daswani (Head of Upper Secondary, Improve ME Institute; MSc Financial Mathematics, Imperial College London; BSc, UCL) and Jason Daswani (operational lead, Improve ME Institute; LSE).